Polynucleotides are an innovative advancement in aesthetic medicine, offering a powerful approach to skin regeneration and anti-aging. As a bio-stimulating injectable treatment, polynucleotides work at a cellular level to stimulate collagen and elastin production, improving skin texture, elasticity, and overall vitality.
Derived from purified marine DNA, typically sourced from salmon or trout, polynucleotides come in the form of a biocompatible gel. Once injected, they activate the skin’s natural repair processes, promote tissue regeneration, and reverse signs of aging—making them an ideal option for facial rejuvenation and skin restoration.
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FAQs
How does it work?
Polynucleotides are one of the newest treatments in the market and are not a filler.
They can take some time to work and rely on the body to start producing collagen and elastin taking a few weeks to happen.
They can be used for collagen stimulation improving the elastin and firmness of the skin, which in turn makes for a tighter and more youthful appearance of the skin.
They also have anti-aging effects and reduce the appearance of fine lines and wrinkles by supporting the natural repair mechanisms of the skin as well as regenerating it.
The overall texture of the skin is improved with polynucleotides as they encourage cell turnover and the renewal of skin cells. The skin appears well hydrated and plumper and tighter.
One of the most excellent properties of polynucleotides are that they have anti-inflammatory properties and can reduce redness and irritation of the skin so very good in treating rosacea.
Finally, the most cutting-edge use is for dark under eye circles. Historically tear trough was used to improve hollowing and darkness, but the dark circles have been seen to improve drastically by inhibition of melanogenesis which contributes to the darkness in the skin tone.
How many treatments do I need?
Polynucleotides are safer than fillers because they wake up your own cells to produce an improvement in the qualities listed above. The results may vary between individuals and don’t happen straight away, unlike fillers.
Usually, 2-4 treatments in total are required which are injected 3-4 weeks apart. One maintenance treatment every 6-9 months is recommended thereafter.
Who will benefit from this?
Polynucleotides are best for treating dark circles under the eyes, lines and wrinkles on the face and neck and skin texture that needs improving.
It works well when combined with fillers and is a great alternative for those who are not suitable for filler under the eyes.
How long does it take to work?
Post Polynucleotides there can be some swelling and that is not the end result. This can take a week or two to settle down and then the results tend to show up after 2 months. The benefits can last for up to 9 months however this can vary between people.
Down time and Side effects?
It is very common to experience mild swelling following a polynucleotide treatment.
This is a normal response and typically settles within a few days. It’s important to note that different brands of polynucleotides vary in concentration, which may influence individual responses.
At Signature Aesthetics, Dr. Gill uses a premium brand of polynucleotides extracted from fish DNA using highly purified technology, ensuring both safety and effectiveness. However, as a precaution, this treatment is not recommended for individuals with fish or shellfish allergies.
Some patients may notice a temporary “sandpaper” texture to the skin during the natural shedding and cell turnover process. This is a normal part of the rejuvenation cycle and typically resolves within a few days, revealing smoother, more radiant skin.